HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2-(4-Hydroxy-piperidin-1-yl)-thiazole-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium Bisulfate | HCID 516919 | — |
| Reactant | Ethyl 2-(4-hydroxypiperidin-1-yl)thiazole-4-carboxylate | HCID 22242823 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Hydroxy-piperidin-1-yl)-thiazole-4-carboxylic acid | HCID 67270511 | 90% |
Reaction Steps
The 2-(4-hydroxy-piperidin-1-yl)-thiazole-4-carboxylic acid ethyl ester mixture from step a was dissolved in MeOH (10 mL). To this was added NaOH (2 M, 5.00 mL). The reaction mixture was stirred overnight, then diluted 1M NaHSO4 (30 mL). This solution was extracted with EtOAc (3×50 mL), and the combined organic layers were dried over Na2SO4, filtered, and concentrated to give the product (433 mg, 1.90 mmol, 90%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09169261B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-fccb14984ec645c4b50818eefee8de0f |
| Source note | uspto-grants-2015_10 |