Potassium Carbonate → HCID 86720525, compound

Participants

Reaction Steps

To a slurry of 2-(trichloroacetyl)pyrrole (380 mg, 1.79 mmol) and K2CO3 (780 mg, 5.7 mmol) in 5 mL acetone was added a solution of 1-bromo-2-butanone (400 mg, 2.7 mmol) in 2 mL acetone. The mixture was stirred for 19 hours at room temperature before filtering and concentrating under reduced pressure to obtain 3-ethyl-1H-pyrrolo[2,1-c][1,4]oxazin-1-one (298 mg, quantitative), which was used in the following step without purification.

Provenance & Evidence