HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1755238Generated: November 4, 2026
Hydrochloric Acid → (S)-1-(pyrazolo[1,5-a]pyrazin-4-yl)pyrrolidin-3-amine
https://huagongshe.com/reaction/1755238
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-tert-butyl (1-(pyrazolo[1,5-a]pyrazin-4-yl)pyrrolidin-3-yl)carbamate | HCID 75204198 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (S)-1-(pyrazolo[1,5-a]pyrazin-4-yl)pyrrolidin-3-amine | HCID 75204199 | 100% |
Reaction Steps
To a solution of (S)-tert-butyl (1-(pyrazolo[1,5-a]pyrazin-4-yl)pyrrolidin-3-yl)carbamate (0.74 g, 2.4 mmol, 1 eq) in 3 mL of dioxane was added a solution of 4.0 M HCl in dioxane (3 mL, 20 mmol, 4 eq). After heating for 3 h at 60° C., the mixture was concentrated to afford (S)-1-(pyrazolo[1,5-a]pyrazin-4-yl)pyrrolidin-3-amine (0.670 g, 2.4 mmol, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09169261B2 |
|---|
| Source dataset | uspto-grants-2015_10 |
|---|
| ORD ID | ord-8150d10c117e437887bc5b622b2ca08e |
|---|
| Source note | uspto-grants-2015_10 |
|---|
