HCID 75204432, compound → HCID 75204433, compound

Participants

Reaction Steps

To a solution of (S)—N-(1-(pyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl)-5-vinylpyrimidine-2-carboxamide (0.04 g, 0.12 mmol, 1 eq) in 1 mL of MeOH was added 10% Pd/C (0.013 g, 0.01 mmol, 0.1 eq). The reaction mixture was equipped with a H2 balloon and stirred for 1 hr at room temperature. The contents were filtered and the purified by HPLC to afford (S)-5-ethyl-N-(1-(pyrrolo[1,2-a]pyrazin-1-yl)pyrrolidin-3-yl)pyrimidine-2-carboxamide (0.009 g, 0.25 mmol, 22%). 1H NMR (400 MHz, CD3OD) δ 8.80 (s, 2 H), 7.76 (m, 1 H), 7.71 (d, J=5.8 Hz, 1 H), 7.54 (s, 1 H), 6.92 (dd, J=2.6, 4.4 Hz, 1 H), 6.84 (d, J=5.5 Hz, 1 H), 5.00-3.60 (br, 5 H), 2.81 (q, J=7.4 Hz, 2 H), 2.65-2.30 (br, 2 H), 1.33 (t, J=7.4 Hz, 3 H); MS: (ES) m/z calculated for C17H18N6O [M+H]+337.2, found 337.

Provenance & Evidence