HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1755290Generated: November 2, 2026
Pyrrolidine → 6-chloro-N-(6-(pyrrolidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine
https://huagongshe.com/reaction/1755290
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 6-chloro-N-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine | HCID 86682695 | — |
| Solvent | Water | HCID 962 | — |
| Product | 6-chloro-N-(6-(pyrrolidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine | HCID 71534383 | 18.4% |
Reaction Steps
A suspension of 6-chloro-N-(6-fluoropyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine (132 mg, 0.5 mmol) and pyrrolidine (54 mg, 0.75 mmol) in water (0.3 mL) was heated to 205° C. in a microwave oven for 30 minutes. The reaction mixture was purified by chromatography (silica gel, 200-300 mesh, CH2Cl2:MeOH=200:1) to give 6-chloro-N-(6-(pyrrolidin-1-yl)pyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine (29 mg, 18%) as a light yellow solid. LC-MS: [M+H]+, 315.0, tR=1.837 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09169259B2 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-80a00eeb38a94c2e92314df655839e2b |
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| Source note | uspto-grants-2015_10 |
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