反应详情

A solution of NaOH in water (0.05 mol/L, 1.2 mL) was added to 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoic acid (25 mg, 0.06 mmol) and the mixture stirred until the solid was completely dissolved. The solution was concentrated in vacuo to give sodium 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzoate (20 mg, 76%) as a white solid. 1H NMR (300 MHz, D2O): δ 7.98-7.77 (m, 2H), 7.55-7.38 (m, 2H), 7.26-7.05 (m, 3H), 6.80 (brs, 1H), 5.50 (brs, 1H), 5.41-5.33 (m, 1H), 3.39 (brs, 1H), 2.91 (brs, 1H), 2.63 (brs, 1H), 1.58-1.30 (m, 4 h), 0.60 (s, 3H).

1. dissolutionwas completely dissolved
2. concentrationThe solution was concentrated in vacuo