(R)-2-Methylpyrrolidine → (R)-6-(2-methylpyrrolidin-1-yl)pyridin-2-amine

Participants

Reaction Conditions

Reaction Steps

A suspension of 6-fluoropyridin-2-amine (448 mg, 4 mmol) and (R)-2-methylpyrrolidine (511 mg, 6 mmol) in water (0.5 mL) was heated to 205° C. in a microwave oven for 30 minutes. The reaction mixture was purified by chromatography (silica gel, 200-300 mesh, petroleum ether:ethyl acetate=3:1) to give (R)-6-(2-methylpyrrolidin-1-yl)pyridin-2-amine (581 mg, 82%) as a light yellow oil. LC-MS: [M+H]+, 178.2, tR=1.049 min.

Provenance & Evidence