2,5-Dimethylpyrrolidine → 6-(2,5-Dimethylpyrrolidin-1-yl)pyridin-2-amine

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Reaction Conditions

Reaction Steps

A mixture of 6-fluoropyridin-2-amine (0.5 g, 4.46 mmol) and 2,5-dimethylpyrrolidine (0.664 g, 6.7 mmol) in water (0.3 mL) was heated to 205° C. for 0.5 h in a microwave oven then concentrated in vacuo. The residue was purified by chromatography (silica gel, 10 g, 200˜300 mesh, ethyl acetate:petroleum ether=1:30) to afford 6-(2,5-dimethylpyrrolidin-1-yl)pyridin-2-amine (0.383 g, 45%) as a yellow oil. LC-MS: [M+1]+=192, tR=1.048 min.

Provenance & Evidence