HCID 71451823, compound → HCID 86682738, compound

Participants

Reaction Conditions

Reaction Steps

(3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)phenyl)methanol (20 mg, 0.05 mmol) and MnO2 (86 mg, 1.0 mmol) were dissolved in dichloromethane (10 mL), the reaction mixture was heated up to 40° C. with stirring for 24 h, filtered, washed with dichloromethane (30 mL) and then the filtrate was concentrated in vacuo to give a solid which was purified by chromatography on a aluminum oxide eluted with dichloromethane to give 3-(8-(6-(2-methylpyrrolidin-1-yl)pyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)benzaldehyde (9 mg, 45%) as an orange solid. LC-MS: 399 [M+H]+, tR=1.88 min.

Provenance & Evidence