反应详情

温度

160 °C

A suspension of 6-chloro-N-(5,6-dimethoxypyridin-2-yl)imidazo[1,2-b]pyridazin-8-amine (1.3 g, 4.24 mmol) and tert-butyl piperidin-3-ylcarbamate (3.4 g, 16.99 mmol) was heated to 160° C. for 2 h. The residue was purified by chromatography (silica gel, 200-300 mesh, dichloromethane:MeOH=120:1) to give the tert-butyl 1-(8-(5,6-dimethoxypyridin-2-ylamino)imidazo[1,2-b]pyridazin-6-yl)piperidin-3-ylcarbamate (300 mg, 15%) as brown solid. LC-MS: 470 [M+1]+, tR=1.44 min

1. customThe residue was purified by chromatography (silica gel, 200-300 mesh, dichloromethane:MeOH=120:1)