HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (2S)-2-((2S)-2-(2-(5-Formylthiazol-2-ylamino)-3-methylbutanamido)propanamido)propanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (2S)-tert-Butyl 2-((2S)-2-(2-(5-formylthiazol-2-ylamino)-3-methylbutanamido)propanamido)propanoate | HCID 89867008 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2S)-2-((2S)-2-(2-(5-Formylthiazol-2-ylamino)-3-methylbutanamido)propanamido)propanoic acid | HCID 89858110 | 145.2% |
Reaction Steps
Following the procedure as described in Example 11, except using material from Example 26 (213 mg, 0.499 mmol), CH2Cl2 (75 mL) and TFA (25 mL, 324 mmol), 268.4 mg (quantitative yield) of the title compound is obtained as a white solid as a mono TFA salt. LC/MS (Condition A): ret. T=2.15 min, (M+H)+ 371.14.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09169295B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-82daa52006804221a035e4477c7d8b38 |
| Source note | uspto-grants-2015_10 |