HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | (S)-tert-Butyl 2-((S)-2-(2-(5-formylthiazol-2-ylamino)acetamido)propanamido)propanoate | HCID 86700126 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | (S)-2-((S)-2-(2-(5-Formylthiazol-2-ylamino)acetamido)propanamido)propanoic acid | HCID 86700127 | — |
Reaction Steps
Following the general procedure as described in Example 68, except using material from Example 101 (780 mg, 2.03 mmol) and HCl, 1.0M in diethyl ether (125 mL, 125 mmol), the title compound is isolated in quantitative yield as a bis HCl salt by weight. LC/MS (Condition A): ret. T=1.3 min, (M+H)+ 329.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09169295B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-9b3cfa1bb3ee4b2ca77a212ff5270eb5 |
| Source note | uspto-grants-2015_10 |