Potassium Carbonate → HCID 86712048, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-phenyl-2-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)-1H-benzo[d]imidazole (Compound 16) (12 mmol), 2-iodo-5-bromo pyridine (6.816 g, 24 mmol), Pd(PPh3)4 (0.69 g, 0.6 mmol) and K2CO3 (3.3 g, 24 mmol) in dioxane/water (100 mL/20 mL) was degassed and heated at 90° C. for 20 hours. The whole was allowed to cool to RT, white precipitate formed. After filtration, a solid (Compound 17) was collected (5.0 g, in 97% yield).

Provenance & Evidence