Potassium Carbonate → HCID 86712052, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-phenyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)naphthalen-1-amine (Compound 29) (2.32 g, 5.51 mmol), 2-iodo-5-bromo-pyridine (3.13 g, 11 mmol), Pd(PPh3)4 (0.346 g, 0.3 mmol) and K2CO3 (1.38 g, 10 mmol) in dioxane/water (60 mL/10 mL) was degassed and heated at about 95° C. overnight. The resulting mixture was mixed with ethyl acetate/brine, dried over Na2SO4, loaded on silica gel, and purified by flash column (hexanes to hexanes/dichloromethane 9:1 to 3:1). The desired fraction was collected and a light yellow solid (Compound 30) was obtained after removal of solvents (2.17 g, in 87% yield).

Provenance & Evidence