Trolox → 6-hydroxy-N-(5-hydroxypentyl)-2,5,7,8-tetramethylchroman-2-carboxamide

HRID 1755560Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1755560
[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([OH:16])=O)[CH2:6][CH2:5]2.C1N=CN(C(N2C=NC=C2)=O)C=1.[NH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][OH:37]>>[OH:1][C:2]1[C:3]([CH3:18])=[C:4]2[C:9](=[C:10]([CH3:13])[C:11]=1[CH3:12])[O:8][C:7]([CH3:17])([C:14]([NH:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][OH:37])=[O:16])[CH2:6][CH2:5]2

Komponenten

4

Edukt 3

HCID 40634TroloxHCID 682631,1'-CarbonyldiimidazoleHCID 756345-Aminopentan-1-ol

Produkt 1

HCID 672629966-hydroxy-N-(5-hydroxypentyl)-2,5,7,8-tetramethylchroman-2-carboxamideAusbeute 70,5 %

Versuchsvorschrift

Following the amide coupling procedure described in protocol A, 497 mg 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (1.98 mmol), 370 mg CDI (2.28 mmol) and 239 mg 5-aminopentanol (2.2 mmol) produced 468 mg of 6-hydroxy-N-(5-hydroxypentyl)-2,5,7,8-tetramethylchroman-2-carboxamide as a pale brown solid.

Quellen und Nachweise

ORD-Eintrag
ord-683cc2621d064b5f967646fa20281efb
Quelldatensatz
uspto-grants-2015_10
Patentnummer
US09169196B2

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