Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → HCID 19917651, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1,5-Hexadien-3-ol | HCID 79122 | — |
| 반응물 | 1,10-Dibromodecane | HCID 221483 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 19917651 | HCID 19917651 | 35% |
반응 단계
10 g of 1,5-hexadien-3-ol was dissolved in 100 ml of tetrahydrofuran (THF), and the atmosphere was replaced with argon. 4.1 g of 60% sodium hydride was added little by little. After hydrogen gas had ceased to generate, a THF solution of 75 g of 1,10-dibromodecane was added, and reflux was carried out for 8 hours. The insoluble matter generated was filtered off, and the solvent was evaporated. The residue was purified by column chromatography, to obtain 11.3 g of the objective compound (1). (Yield: 35%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05437816 |
| 출처 데이터셋 | uspto-grants-1995_08 |
| ORD ID | ord-5d8b5db9cb2440608eab08faa8463c29 |
| 출처 메모 | uspto-grants-1995_08 |