反应详情

A solution of 16.5 g of 4-propylphenylboric acid as dissolved in 130 ml of ethanol was dropwise added to a mixture comprising 30 g of 1-bromo-2-fluoro-4-iodobenzene, 1.6 g of tetrakistriphenylphosphine palladium(O), 186 ml of benzene and 140 ml of 2M aqueous sodium carbonate solution, in nitrogen atmosphere at room temperature. The reaction solution was then refluxed for 5 hours, cooled to room temperature, extracted with chloroform and washed three times with water, and chloroform was removed by distillation. The residue formed was distilled under reduced pressure (b.p. 155° to 170° C./3 mmHg) to obtain 11.7 g of 4-bromo-3-fluoro-4'-propylbiphenyl.

1. temperatureThe reaction solution was then refluxed for 5 hours
2. extractionextracted with chloroform
3. washwashed three times with water, and chloroform
4. customwas removed by distillation
5. customThe residue formed
6. distillationwas distilled under reduced pressure (b.p. 155° to 170° C./3 mmHg)