Ethyl Acetate → HCID 10381871, compound

Participants

Reaction Steps

(Trimethylsilyl)acetylene (1.18 mL, 8.4 mmol), copper(I) iodide (0.05 g, 0.28 mmol) and bis(triphenylphosphine)palladium(II) chloride (0.1 g, 0.14 mmol) are added sequentially to a degassed suspension of 4-tert-butyl-3,4-dihydro-7-iodo-1H-1,4-benzodiazepine-2,5-dione (2.5 g, 7.0 mmol) in triethylamine. The reaction mixture is stirred at room temperature for 5 hours and filtered. The filtrate is diluted with ether and concentrated in vacuo to obtain a solid. Chromatography of the solid using silica gel and 15% to 20% ethyl acetate in hexanes solutions gives the title product as a light brown solid (1.33 g, mp 243°-244° C.).

Provenance & Evidence