Sodium Hydroxide → HCID 10400178, compound

Participants

Reaction Steps

1N Sodium hydroxide solution (3.4 mL) is added to a suspension of 4-tert-butyl-3,4-dihydro-7-[(trimethylsilyl)ethynyl]-1H-1,4-benzodiazepine-2,5-dione (1.0 g, 3.0 mmol) in methanol. The reaction mixture is stirred at room temperature for 2 hours, concentrated in vacuo and extracted with ethyl acetate. The combined organic extracts are washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo to give the title product as a light brown solid (0.66 g, mp 216°-219° C.).

Provenance & Evidence