Etidronic Acid → HCID 23422034, compound

HRID 1755638Notes

Reaction equation

HRID 1755638 reaction equation
[OH:1][C:2]([P:8](=[O:11])([OH:10])[OH:9])([P:4](=[O:7])([OH:6])[OH:5])[CH3:3].[CH:12](Cl)(Cl)Cl.[N+](=C)=[N-]>CCOCC>[CH3:12][O:11][P:8]([C:2]([P:4](=[O:6])([OH:5])[OH:7])([OH:1])[CH3:3])(=[O:9])[OH:10]

Participants

5

Reactant 3

HCID 3305Etidronic AcidHCID 6212ChloroformHCID 9550Diazomethane

Product 1

HCID 23422034HCID 23422034, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Finely ground (1-hydroxyethylidene)bisphosphonic acid (0.005 moles) was mixed with 100 ml of chloroform and to the mixture 25 ml of an appr. 2% ether solution of diazomethane were slowly added at room temperature. After the addition, the mixing was continued for 1 hour, whereafter the solution was evaporated at reduced pressure (yield 42%, 31-P NMR 17.25/24.84 ppm, J=27.3; D2O).

Workup

  1. additionAfter the addition
  2. customwas evaporated at reduced pressure (yield 42%, 31-P NMR 17.25/24.84 ppm, J=27.3; D2O)

Sources & evidence

ORD record
ord-1aba4f0ef15746aa841a55af41dccb5e
Source dataset
uspto-grants-1995_08
Patent number
US05438048

Reaction notes

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