m-Chloroperbenzoic acid → HCID 178432865, compound

Participants

Reaction Conditions

Reaction Steps

50.23 g (0.35 mol) of 2-methyl-4-amino-6-chloropyrimidine are partially dissolved in 700 ml of methanol. The mixture is cooled to 0° C. and 131.7 g (0.42 mol) of approximately 55% m-chloroperbenzoic acid are introduced, in small fractions, with good stirring, at a rate such that the temperature remains below 5° C. After the end of the introduction, the mixture is kept below 5° C. for a further 3 hours and is then allowed to return to ambient temperature. After 4 hours at 20° C., only traces of starting material still remain. The mixture is left to freeze overnight. The following day the precipitate is drained and washed with 30 ml of cold methanol. The precipitate is taken up in 120 ml of iced methanol, with stirring. The solid is drained and dried. 27.4 g of pure product having a melting point of 191° C. are obtained.

Provenance & Evidence