HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1755776Generated: November 3, 2026
1-Chloro-2-iodobenzene → 3-(2-Chlorophenyl)-1-(3-(2-(6,7-difluoro-2-quinolinyl)ethenyl)phenyl)-1-propanone
https://huagongshe.com/reaction/1755776
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Chloro-2-iodobenzene | HCID 11993 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | 1-(3-(2-(6,7-Difluoro-2-quinolinyl)ethenyl)phenyl)-2-propen-1-ol | HCID 53942224 | — |
| Reactant | lithium;acetate;dihydrate | HCID 178526966 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2-Chlorophenyl)-1-(3-(2-(6,7-difluoro-2-quinolinyl)ethenyl)phenyl)-1-propanone | HCID 53728050 | — |
Reaction Steps
A mixture of the allylic alcohol of Step 3 (1.214 g, 3.75 mmol), 1-chloro-2-iodobenzene (480 FtL), Pd(OAc)2 (30 mg), LiCl (194 mg), LiOAc.2H2O (995 rag) and Bu4NCI (2.13 g) in 7.5 mL of DMF was degassed under vacuum and heated to 100° C. under N2 for 3 hr. 25% Aq. NH4OAc was then added and the product was extracted in EtOAc, dried over Na2SO4, and purified by flash chromatography with EtOAc: toluene 2.5:97.5. Yield 1.53 g, 94%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05438141 |
|---|
| Source dataset | uspto-grants-1995_08 |
|---|
| ORD ID | ord-930cef5125954df69172621cf29c67a1 |
|---|
| Source note | uspto-grants-1995_08 |
|---|
