HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isophthalaldehyde → 3-(Hydroxymethyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isophthalaldehyde | HCID 34777 | — |
| Reactant | Ammonium Acetate | HCID 517165 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(Hydroxymethyl)benzaldehyde | HCID 13131455 | 46.3% |
Reaction Steps
To isophthalaldehyde (200 g) in absolute ethanol (3 L) at 0° C. was added NaBH4 (15.6 g). After 1 hour at O° C. the reaction mixture was poured onto 25% aqueous ammonium acetate (2 L). The ethanol was evaporated and the product was extracted with EtOAc. The resulting mixture was purified by flash chromatography (30% EtOAc/Hexane) to provide 94 g of the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05438141 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-11e98644f9bb4c2fbbfd03e72b778ad2 |
| Source note | uspto-grants-1995_08 |