Hydrochloric Acid → 3-[2(R)-Hydroxypropyl]amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-[(t-butoxycarbonylamino)methyl][1,1'-biphenyl]-4-yl]methyl]-1H-benzazepin-3(R)-yl]butanamide

Participants

Reaction Steps

To a solution of 525 mg (0.695 mmol) of the intermediate prepared in Step A in 6 mL of methanol was added 0.350 mL (0.700 mmol) of 2N hydrochloric acid and 100 mg (20% w/w) of 30% palladium on carbon. The resulting mixture was shaken under a hydrogen atmosphere at 40 psi for 24 hours. The catalyst was removed by filtration through Celite and the solvent removed under vacuum. The residue was purified by column flash chromatography on silica gel, eluting with chloroform/10% ammonium hydroxide in methanol (95/5), to give 415 mg (95%) of the product as a white solid. 1H NMR (400 MHz, CD3OD): δ1.12-1.21 (m, 9H), 1.42 (s, 9H), 2.04-2.13 (m, 1H), 2.22-2.41 (m, 3H), 2.49-2.62 (m, 4H), 3.80-3.88 (m, 1H), 4.09 (s, 2H), 4.42 (dd; 12, 4 Hz; 1H), 4.97 (d, 15 Hz, 1H), 5.30 (d, 15 Hz, 1H), 7.11-7.42 (m, 12 H). FAB-MS: calculated for C37H48N4O5 628; found 629 (M+H).

Provenance & Evidence