2'-[(t-Butoxycarbonylamino)methyl]-1,1-biphenyl-4-methanol → HCID 22855148, compound

HRID 1755797Notes

Reaction equation

HRID 1755797 reaction equation
[CH2:1]([O:8][C@H:9]([CH3:31])[CH2:10][NH:11][C:12]([CH3:30])([CH3:29])[CH2:13][C:14]([NH:16][C@H:17]1[C:23](=[O:24])[NH:22][C:21]2[CH:25]=[CH:26][CH:27]=[CH:28][C:20]=2[S:19][CH2:18]1)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:32]([O:36][C:37]([NH:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1[C:47]1[CH:52]=[CH:51][C:50]([CH2:53]O)=[CH:49][CH:48]=1)=[O:38])([CH3:35])([CH3:34])[CH3:33]>>[CH2:1]([O:8][C@H:9]([CH3:31])[CH2:10][NH:11][C:12]([CH3:30])([CH3:29])[CH2:13][C:14]([NH:16][C@H:17]1[C:23](=[O:24])[N:22]([CH2:53][C:50]2[CH:49]=[CH:48][C:47]([C:42]3[CH:43]=[CH:44][CH:45]=[CH:46][C:41]=3[CH2:40][NH:39][C:37]([O:36][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:38])=[CH:52][CH:51]=2)[C:21]2[CH:25]=[CH:26][CH:27]=[CH:28][C:20]=2[S:19][CH2:18]1)=[O:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 220084722'-[(t-Butoxycarbonylamino)methyl]-1,1-biphenyl-4-methanolHCID 22855147HCID 22855147, compound

Product 1

HCID 22855148HCID 22855148, compound

Procedure

This intermediate is prepared from 3-[2(R)-benzyloxypropyl]amino-3-methyl-N-[3,4-dihydro-4-oxo-1,5-benzothiazepin-3 (S )yl]butanamide (Example 10, Step C) and 2'-[(t-butoxycarbonylamino)methyl]-1,1 '-biphenyl-4-methanol, methanesulfonate ester (Example 8, Step F) by the procedure described in Example 1, Step D.

Sources & evidence

ORD record
ord-b1b94b7ce7384837ba901d331ef0b56d
Source dataset
uspto-grants-1995_08
Patent number
US05438136

Reaction notes

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