Carbon Dioxide → HCID 11129651, compound

Participants

Reaction Steps

Benzyloxycarbonyl-L-alanine (15.0 g) (67.2 mmol) was dissolved in methylene chloride with about 1 mL of concentrated sulfuric acid. Isobutylene was added via a dry-ice, cold finger trap. The solution was allowed to warm to room temperature and left stirring overnight. The solution was charged with isobutylene again and left stirring overnight. The solution was extracted with 0.8N aqueous sodium bicarbonate, dried over anhydrous magnesium sulfate, filtered and evaporated under vacuum to give benzyloxycarbonyl-L-alanine t-butyl ester. 1H NMR (CDCl3) δ7.35 (s, 5H), 5.12 (s, 2H), 4.23 (m, 2H), 1.45-1.30 (s/d, 12H).

Provenance & Evidence