HCID 19918581, compound → 2-Benzyl-3-hydroxypropanoic acid

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Reaction Steps

benzyl 2-benzyl malonate (75) is treated with lithium aluminum hydride in THF at -78° C. The reaction is allowed to warm to room temperature and then is quenched with aqueous HCl. The reaction mixture is diluted with water and extracted with ethyl acetate. After drying over Na2SO4, the ethyl acetate is evaporated and the product purified by flash chromatography over silica gel to give (76).

Provenance & Evidence