Ammonia → HCID 178429172, compound

HRID 1755832Notes

Reaction equation

HRID 1755832 reaction equation
Cl[CH2:2][C:3]1[N:13]=[C:6]2[N:7]=[C:8]([CH3:12])[CH:9]=[C:10]([OH:11])[N:5]2[N:4]=1.[NH3:14]>>[NH2:14][CH2:2][C:3]1[N:13]=[C:6]2[N:7]=[C:8]([CH3:12])[CH:9]=[C:10]([OH:11])[N:5]2[N:4]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 178429169HCID 178429169, compound

Product 1

HCID 178429172HCID 178429172, compound

Procedure

2-(Chloromethyl)-5-methyl-s-triazolo[1.5-a]pyrimidin-7-ol (1.0 g) (known from C.A. 104/09-068678) is dissolved in 20 ml of conc. aqueous ammonia and stirred at room temperature overnight. The precipitate formed is filtered off under suction. The mother liquor is concentrated and the residue is taken up in ethanol. The product thereby crystallizes. There is obtained 0.66 g of 2-(aminomethyl)-5-methyl-s-triazolo[1,5-a]pyrimidin-7-ol as a white powder of m.p. 204°-207° C.

Workup

  1. customThe precipitate formed
  2. filtrationis filtered off under suction
  3. concentrationThe mother liquor is concentrated
  4. customThe product thereby crystallizes

Sources & evidence

ORD record
ord-63b3560a87a74db8a93e3a4d9305c65f
Source dataset
uspto-grants-1995_08
Patent number
US05438052

Reaction notes

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