Boron tribromide → HCID 19918016, compound

Participants

Reaction Conditions

Reaction Steps

N-[[5-(Benzyloxy)-4-oxo-4H-pyran-2-yl]methoxy]-phthalimide (1.77 g) (4.7 mmol) are suspended in 250 ml of dichloromethane and treated at -70° C. with 1.32 g (5.2 mmol) of boron tribromide (dissolved in 5 ml of dichloromethane). The mixture is stirred at -70° C. for 3 hours and at room temperature for 20 hours. The solvent is removed in a vacuum and the residue is treated at 0° C. with about 70 ml of water and 10 ml of ethanol. After stirring for 2 hours the product is filtered off and washed in succession with water, ethanol and diethyl ether. There are obtained 1.3 g of N-[(5-hydroxy-4-oxo-4H-pyran-2-yl)methoxy]phthalimide as a white powder of m.p. 200°-203° C. (dec.).

Provenance & Evidence