反应详情

(3,4-Dimethoxyphenyl)malonaldehyde acid methyl ester (7.2 g) (30 mmol) and 10 g (42 mmol) of benzamidine are melted at 100° C. The reaction mixture is chromatographed on 250 g of silica gel (0.063-0.2 mm) and the product is eluted with dichloromethane/methanol (9:1 v/v). The eluate is concentrated in a vacuum at 45° C. and the crystalline product is filtered off under suction. The whole is washed with diethyl ether and dried in a high vacuum at room temperature. There are obtained 6.2 g of 5-(3,4-dimethoxyphenyl)-2-phenyl-6(1H)-pyrimidinone as yellow crystals of m.p. 230° C.

1. customThe reaction mixture is chromatographed on 250 g of silica gel (0.063-0.2 mm)
2. washthe product is eluted with dichloromethane/methanol (9:1 v/v)
3. concentrationThe eluate is concentrated in a vacuum at 45° C.
4. filtrationthe crystalline product is filtered off under suction
5. washThe whole is washed with diethyl ether
6. customdried in a high vacuum at room temperature