Diethyl Ether → 4-(3,4-Dihydro-4-oxo-2-phenyl-5-pyrimidinyl)-o-phenylene diacetate

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Reaction Steps

5-(3,4-Dihydroxyphenyl)-2-phenyl-4(3H)-pyrimidinone hydrobromide (6.0 g) (21.4 mmol) are dissolved in 100 ml of pyridine and treated at room temperature while stirring with 5.2 g (51 mmol) of acetic anhydride. After 1.5 hours 200 ml of diethyl ether are added thereto and the precipitated product is filtered off. The solid is washed with diethyl ether and dried in a high vacuum at 35° C. There are obtained 7.1 g of 4-(3,4-dihydro-4-oxo-2-phenyl-5-pyrimidinyl)-o-phenylene diacetate as white crystals of m.p. 240° C.

Provenance & Evidence