Diisopropylethylamine → HCID 19917925, compound

Participants

Reaction Steps

Methyl 2-formyl-2-(3,4-dimethoxyphenyl)acetate (7.2 g) (30 mmol), 4.8 g (60 mmol) of formamidine hydrochloride and 7.74 g (60 mmol) of N-ethyldiisopropylamine (Hunig base) are stirred in 60 ml of ethanol for 55 hours at 50° C. and subsequently concentrated in a vacuum. The residue is washed several times with diethyl ether and then crystallized using ethanol/diethyl ether. The yellowish product is filtered off under suction, washed with ethanol/diethyl ether and dried in a high vacuum at room temperature. There are obtained 1.6 g of 5-(3,4-dimethoxyphenyl)-4(3H)-pyrimidinone of m.p. 205°-206° C.

Provenance & Evidence