反应详情

A mixture of 71 mg (0.5 mmol) of methyl 5-amino-4H-s-triazole-3-carboxylate and 188 mg of ethyl 4-acetoxy-3-oxo-butyrate is held at about 160° C. for 40 minutes. After cooling the product is crystallized and recrystallized from methanol. There are obtained 110 mg of methyl 5-(acetoxymethyl)-4,7-dihydro-7-oxo-s-triazolo[1,5-a]pyrimidine-2-carboxylate as beige crystals of melting point 223° C. (dec.).

1. temperatureAfter cooling the product
2. customis crystallized
3. customrecrystallized from methanol