Thiourea → HCID 178429715, compound

HRID 1755924Notes

Reaction equation

HRID 1755924 reaction equation
[N:1]([CH2:4][C:5]1[N:15]=[C:8]2[N:9]=[C:10]([CH3:14])[CH:11]=[C:12](Cl)[N:7]2[N:6]=1)=[N+:2]=[N-:3].NC(N)=[S:18]>C(O)C>[N:1]([CH2:4][C:5]1[N:15]=[C:8]2[N:9]=[C:10]([CH3:14])[CH:11]=[C:12]([SH:18])[N:7]2[N:6]=1)=[N+:2]=[N-:3]

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 199179332-Azidomethyl-7-chloro-5-methyl[1.2.4]triazolo[1,5-a]pyrimidine

Product 1

HCID 178429715HCID 178429715, compoundYield 93.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-Azidomethyl-7-chloro-5-methyl[1.2.4]triazolo-[1,5-a]pyrimidine (2.98 g) are suspended in 70 ml of ethanol, treated with 1.1 g of thiourea and heated at reflux for 45 minutes. The reaction mixture is stirred in an ice bath for 30 minutes. The resulting precipitate is filtered off under suction and dried in a vacuum at 40° C. There are obtained 2.76 g of 2-azidomethyl-5methyl[1.2.4]triazolo[1,5-a]pyrimidine-7-thiol as yellow crystals of melting point 214°-215° C.

Workup

  1. temperatureheated
  2. temperatureat reflux for 45 minutes
  3. filtrationThe resulting precipitate is filtered off under suction
  4. customdried in a vacuum at 40° C

Sources & evidence

ORD record
ord-937c5193da354e5da954000b19cd3d47
Source dataset
uspto-grants-1995_08
Patent number
US05438052

Reaction notes

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