Hydrochloric Acid → HCID 67696855, compound

Participants

Reaction Steps

A solution of (Z)-3-[2-(5-methyl-2-phenyl-4-oxazolyl) methyl- 5-benzofuranyl]-2-methoxy-2-propenenitrile (0.10 g, 0.27 mmol) in methanol (10 ml) and sodium hydroxide (2 ml) was heated to reflux for 3 hours then cooled, acidified with 6N hydrochloric acid and extracted with ethyl acetate. The combined extracts were washed with brine, dried over magnesium sulfate and concentrated. The product was purified by flash chromatography (ethyl acetate/methanol/acetic acid, 75:1:1) and obtained as a solid (31 mg, m.p. 166°-169° C.).

Provenance & Evidence