Hydroxylamine → HCID 136444127, compound

Participants

Reaction Steps

A solution of 2-acetyl-4-trifluoromethylpyridine (1.2 g), hydroxylamine (0.495 g) and sodium acetate (2.2 g) in a mixture of ethanol:water (20:10 ml) was heated under reflux for 2 hours. The reaction mixture was poured into water and extracted with ethyl acetate (×2). The combined extracts were washed with water, dried and concentrated to give a solid which was washed with hexane to give (E)-2-acetyl-4-trifluoromethylpyridine oxime (1.0 g, 77% yield) as a pale pink solid; 1H NMR (270 MHz): δ2.39(3H,s), 7.47(1H,d), 7.89(1H,brs), 8.12(1H,s), 8.12(1H,s), 8.78(1H,d); ppm.

Provenance & Evidence