Trimethylamine → HCID 19392528, compound

Participants

Reaction Steps

The 2-chloro-4-(2,2,2-trifluoroethoxy)-pyrimidine (142 g) in toluene (330 ml) was added to trimethylamine (140 ml of a 45% aqueous solution) at 0° C. After stirring for 16 hours the organic phase was separated off. The aqueous phase was added to toluene (330 ml) then a solution potassium cyanide (44 g in 170 ml water) was added at 0° C. The reaction mixture was stirred for a further 16 hours and then the organic phase was separated, the aqueous was extracted with ether (2×200 ml) and the combined organic extracts were dried and concentrated to give 2-cyano-4-(2,2,2-trifluoroethoxy)-pyrimidine (73.5 g, 77% yield) as a yellow oil; 1H NMR (270 MHz): δ4.85(2H,q), 7.10(1H,d), 8.64(1H,d) ppm.

Provenance & Evidence