Hydrochloric Acid → HCID 19392516, compound

Participants

Reaction Conditions

Reaction Steps

Methyl magnesium bromide (115 ml of a 3.0M solution in ether) was added to 2-cyano-4-(2,2,2-trifluoroethoxy)-pyrimidine (70.0 g) in THF (300 ml) at -40° C. After the addition it was stirred for 11/2 hours at -40° C. then treated with water (50 ml), followed by enough 2M hydrochloric acid to make the reaction mixture just acid, this was stirred for 11/2 hours and then neutralised with sodium bicarbonate, and extracted with ether (3×300 ml). The combined ether extracts were dried and concentrated to give 2-acetyl-4-(2,2,2-trifluoroethoxy)-pyrimidine (66.8 g, 88% yield) as a brown oil; IR maxima (film): 1718 cm-1 ; 1H NMR (270 MHz): δ2.74(3H,s), 4.92(2H,q), 7.05(1H,d), 8.74(1H,d) ppm.

Provenance & Evidence