HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nicotinoyl chloride → 7-Nicotinoyloxy-2-{4-[bis-(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-1,4-benzodioxin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nicotinoyl chloride | HCID 82604 | — |
| Reactant | 7-Hydroxy-2-{4-[bis(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-1,4-benzodioxin | HCID 10994231 | — |
| Product | 7-Nicotinoyloxy-2-{4-[bis-(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-1,4-benzodioxin | HCID 19392473 | 78% |
Reaction Steps
That compound is obtained in a yield of 78% starting from 7-hydroxy-2-{4-[bis-(4-fluorophenyl)methyl]piperazin-1-ylcarbonyl}-1,4-benzodioxin and nicotinoyl chloride by proceeding as for Example 53. ##STR78##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05439909 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-2ec44bec3d9c435288fa79b8ed1bb428 |
| Source note | uspto-grants-1995_08 |