HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 2-Chloro-3-methyl-7-(2-phenylethyl)pyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Phenethyl bromide | HCID 7666 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine | HCID 19392586 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Chloro-3-methyl-7-(2-phenylethyl)pyrrolo[2,3-b]pyridine | HCID 19916799 | — |
Reaction Steps
A solution of 0.1 g (0.6 mmol) 2-chloro-3-methylpyrrolo-[2,3-b]pyridine and 0.14 g (0.78 mmol) (2-bromoethyl)-benzene in 10 ml acetonitril was refluxed 72 h. The solvent was evaporated. The solid that formed was treated with ether and ethyl acetate and isolated by filtration. Chromatography on silica gel eluting with methylene chloride and methanol (10:1) gave the desired product. (0.03 g 18% ).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05439917 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-d8291cf468cb42cb8ec1469939137576 |
| Source note | uspto-grants-1995_08 |