HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroacetophenone → 2,3-Dimethyl-7-phenacylpyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroacetophenone | HCID 10757 | — |
| Reactant | 2,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine | HCID 12532387 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2,3-Dimethyl-7-phenacylpyrrolo[2,3-b]pyridine | HCID 19916789 | — |
Reaction Steps
A solution of 2,3-dimethylpyrrolo[2,3-b]pyridine (146 mg, 1 mmol) and phenacyl chloride (170 mg, 1.1 mmol) in 3 ml CH3CN was refluxed for 4.5 h. The mixture was allowed to cool and the precipitated product filtered off and washed with a small volume of ice cold CCl4 affording 207 mg (69%) pure title compound as the hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05439917 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-94867da8d84b4f77b6b178a7617a42b4 |
| Source note | uspto-grants-1995_08 |