2-Chloro-4'-fluoroacetophenone → 2-Chloro-3-methyl-7-(p-fluorophenacyl)pyrrolo [2,3-b]pyridine hydrochloride

Participants

Reaction Steps

A solution of 1,2 g (7,2 mmol) 2-chloro-3-methylpyrrolo[2,3-b]pyridine and 1,5 g (8,7 mmol) p-fluorophenacyl chloride in 50 ml acetonitrile was refluxed for 48 h. The mixture was allowed to cool and the precipitated product filtered off. The solid was treated with ethyl acetate and filtered off again affording 1,4 g (57%) of the desired product.

Provenance & Evidence