2-Chloroacetophenone → HCID 19392611, compound

HRID 1756060Notes

Reaction equation

HRID 1756060 reaction equation
[CH3:1][C:2]1[NH:14][C:5]2=[N:6][CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=[C:4]2[C:3]=1[CH3:15].Cl[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19]>>[CH3:1][C:2]1[N:14]=[C:5]2[N:6]([CH2:17][C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[O:19])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[CH:9]=[C:4]2[C:3]=1[CH3:15]

Participants

3

Reactant 2

HCID 107572-ChloroacetophenoneHCID 19916766HCID 19916766, compound

Product 1

HCID 19392611HCID 19392611, compound

Procedure

A solution of 0,1 g (0,47 mmol) 2,3-dimethyl-5-trifluoromethyl-pyrrolo[2,3-b]pyridine and 0,13g (0,84 mmol) 2-chloroacetophenone in 5 ml acetronitrile was refluxed for 48 h. The solvent was evaporated. Chromatography on silica gel eluting with methylene chloride and methanol (100:5) gave the desired product. (0,023 g 15%).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-31c19f7a4f614b9a902d6d445af57dec
Source dataset
uspto-grants-1995_08
Patent number
US05439917

Reaction notes

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