HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethyl bromide → 2,3-Dimethyl-6-methylthio-7-phenethylpyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethyl bromide | HCID 7666 | — |
| Reactant | 2,3-Dimethyl-6-mehylthiopyrrolo[2,3-b]pyridine | HCID 19392610 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2,3-Dimethyl-6-methylthio-7-phenethylpyrrolo[2,3-b]pyridine | HCID 19392581 | 13.5% |
Reaction Steps
A refluxing solution of 2,3-dimethyl-6-mehylthiopyrrolo[2,3-b]pyridine (100 mg, 0.5 mmol) in 5 ml CH3CN was treated with five portions of phenethyl bromide (85 μl, 1.2 mmol), one each 24 h. The solvent was evporated and the residue chromatographed (silica, CH2Cl2 saturated with NH3 /diethyl ether/petroleum ether; 5/2/3) affording 20 mg (13%) pure title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05439917 |
| Source dataset | uspto-grants-1995_08 |
| ORD ID | ord-846f110eaa5b4ec9ba36573368649fbd |
| Source note | uspto-grants-1995_08 |