反应详情

A mixture of 3-(cyanomethyl)-5-fluoro-2-methylpyrrolo[2,3-b]pyridine (10mg, 0.053 mmol) and 4-fluorophenacyl chloride (19 mg, 0.11 mmol) in acetonitrile (0.2 ml) was refluxed under argon for 26 h, during which time the initial solution was transformed into a suspension. Then the suspension was allowed to reach room temperature, diluted with diethyl ether (2ml), and filtered. The crystalline product was washed with diethyl ether to give 8 mg (42%) of the title compound.

1. customto reach room temperature
2. filtrationfiltered
3. washThe crystalline product was washed with diethyl ether