反应详情

To a solution of 0,7 g (5.3 mmol) of 2-methylpyrrolo[2,3-b]pyridine in 2,5 ml glacial acetic acid was added dropwise 0,8 g (5.9 mmol) of sulfuryl chloride at room temperature and with stirring. The reaction mixture was stirred for 1 hour. The solvent was evaporated and the residue was partitioned between methylene chloride and a saturated sodium bicarbonate solution. The organic layer was dried over sodium sulfate and the solvent was evaporated. The residue was crystallized from ether: ethyl acetate, 5:1 to give 0,45 g (51%) of the title compound.

1. stirringThe reaction mixture was stirred for 1 hour
2. customThe solvent was evaporated
3. customthe residue was partitioned between methylene chloride
4. dry with materialThe organic layer was dried over sodium sulfate
5. customthe solvent was evaporated
6. customThe residue was crystallized from ether