反应详情

2,3-dimethylpyrrolo[2,3-b]pyridine 0,5 g (0.0034 mol) was treated in 7 ml acetic acid with an equimolecular amount of bromine and after 5 min a yellow precipitate was formed. The solid was filtred off and treated with 20 ml methanol. The mixture was refluxed for 30 min. and was then evaporated. The residue was partitioned between methylene chloride and bicarbonate solution. The organic layer was separated dried over Na2SO4 and evaporated. The residue was treated with boiling petroleumether (60-80) which was decantated and allowed to cool. The precipitated product was filtred off affording 0,13 g (22%) as white solid.

1. customwas formed
2. temperatureThe mixture was refluxed for 30 min.
3. customwas then evaporated
4. customThe residue was partitioned between methylene chloride and bicarbonate solution
5. customThe organic layer was separated
6. dry with materialdried over Na2SO4
7. customevaporated
8. additionThe residue was treated
9. temperatureto cool
10. customaffording 0,13 g (22%) as white solid