Sodium Hydroxide → HCID 178437192, compound

HRID 1756130Notes

Reaction equation

HRID 1756130 reaction equation
O[CH:2]([C:18]1[N:19]=[CH:20][NH:21][CH:22]=1)[CH2:3][CH2:4][CH:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.S([O-])(O)(=O)=O.[K+].[OH-].[Na+]>C(O)C>[C:12]1([CH:5]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:4][CH:3]=[CH:2][C:18]2[N:19]=[CH:20][NH:21][CH:22]=2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 516920Potassium bisulfateHCID 178520536HCID 178520536, compound

Product 1

HCID 178437192HCID 178437192, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(1-hydroxy-4,4-diphenylbutyl)-1H-imidazole (3,0 g) and 20 g of anhydrous potassium hydrogen sulfate are heated at 150° C. for 4 hours. The mixture is cooled and 90 ml ethanol is added to dissolve the product. The mixture is made alkaline with sodium hydroxide. The product is extracted into methylene chloride, washed with water and evaporated to dryness. The product is then made to hydrochloride salt with dry hydrogen chloride in ethyl acetate. M.p. above 240° C.

Workup

  1. temperatureThe mixture is cooled
  2. dissolutionto dissolve the product
  3. extractionThe product is extracted into methylene chloride
  4. washwashed with water
  5. customevaporated to dryness

Sources & evidence

ORD record
ord-2ab74fa35520483dbc41605717fa810c
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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