HCID 178418361, compound → HCID 178505676, compound

HRID 1756136Notes

Reaction equation

HRID 1756136 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:20]2[N:21]=[CH:22][NH:23][CH:24]=2)=[CH:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:5][CH:4]=1.[H][H]>C(O)C.[Pd]>[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH:9]([C:20]2[N:21]=[CH:22][NH:23][CH:24]=2)[CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compound2×HCID 178478951HCID 178478951, compound

Product 1

HCID 178505676HCID 178505676, compoundYield 82%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4-[1-(4-fluorophenyl)-5-phenyl-1-pentenyl]-1H-imidazole hydrochloride (2,0 g) is dissolved in ethanol and a catalytic amount 10% Pd/C is added. The reaction mixture is agitated vigorously at room temperature in a hydrogen atmosphere until the uptake of hydrogen ceases. The mixture is filtered and the filtrate is evaporated to dryness. The residue which is the product is purified by flash chromatography eluting with methylene chloride-methanol mixture. Yield 82%.

Workup

  1. filtrationThe mixture is filtered
  2. customthe filtrate is evaporated to dryness
  3. customis purified by flash chromatography
  4. washeluting with methylene chloride-methanol mixture

Sources & evidence

ORD record
ord-0fb1d027e2b749058abb2a7af171b337
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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