1-(3-Bromopropyl)-4-fluorobenzene → HCID 19916873, compound

HRID 1756142Notes

Reaction equation

HRID 1756142 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10]Br)=[CH:4][CH:3]=1.[CH2:12]([N:19]1[C:23]([C:24]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=2)=[O:25])=[CH:22][N:21]=[CH:20]1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH2:12]([N:19]1[C:23]([C:24]([C:26]2[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=2)([OH:25])[CH2:10][CH2:9][CH2:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)=[CH:22][N:21]=[CH:20]1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 147371331-(3-Bromopropyl)-4-fluorobenzeneHCID 19916867HCID 19916867, compound

Product 1

HCID 19916873HCID 19916873, compound

Procedure

1-benzyl-5-[1,4-bis(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole is prepared analogously to Example 7 a) starting from 3-(4-fluorophenyl)-1-bromopropane and 1-benzyl-5-[1-(4-fluorophenyl)-1-oxomethyl]-1H-imidazole. The product is purified by flash chromatography.

Workup

  1. customThe product is purified by flash chromatography

Sources & evidence

ORD record
ord-e69c302a6a334037a102cf05b09121a8
Source dataset
uspto-grants-1995_08
Patent number
US05439928

Reaction notes

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